Bone Development and Healing - a photo on Flickriver

Bone Development and Healing

            During normal bone development and fracture healing, cartilage is transformed into bone. Osteoclasts, a specialized type of cell, eat the cartilage, creating a passageway for blood vessels, marrow, and other bone cells. In this image of cartilage (purple and white) from a young mouse femur, osteoclasts (red) surround a blood vessel filled with red blood cells (yellow). In contrast to normal osteoclasts, the cells seen here have only a single nucleus due to the lack of a gene involved in osteoclast development. This research program aims to understand how large, bone resorbing osteoclasts form, and whether preventing them from fusing together is a way to control bone loss in osteoporosis, arthritis, or other conditions. This image was a winner in the 2015 BioArt contest of the Federation of American Societies for Experimental Biology (FASEB).
 
Credit: Paul R. Odgren, Ph.D., University of Massachusetts Medical School

Funded by: National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health

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Taken on: November 7, 2016

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